2. Signaling Pathways
  3. Immunology/Inflammation
    Vitamin D Related/Nuclear Receptor
  4. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor

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Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0243
    Meprednisone
    		Agonist 99.53%
    Meprednisone is a glucocorticoid and a methylated derivative of prednisone.
    Meprednisone
  • HY-13570
    Betamethasone
    		Agonist 99.91%
    Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis.
    Betamethasone
  • HY-N0835
    (20S)-Protopanaxatriol
    		Agonist 99.91%
    (20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects.
    (20S)-Protopanaxatriol
  • HY-N0583R
    Hydrocortisone (Standard)
    		Agonist 99.91%
    Hydrocortisone (Standard) is the analytical standard of Hydrocortisone. This product is intended for research and analytical applications. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
    Hydrocortisone (Standard)
  • HY-B1832
    Prednisone acetate
    		Agonist 99.92%
    Prednisone acetate (Prednisone 21-acetate), a glucocorticoid, is an orally active Notch inhibitor. Prednisone acetate has anti-inflammatory activity and can enhance the immune response.
    Prednisone acetate
  • HY-17461A
    Cortisone acetate
    		Agonist 98.94%
    Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations.
    Cortisone acetate
  • HY-17358
    Loteprednol Etabonate
    		Agonist 99.53%
    Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflammatory activity and has been used in optometry and ophthalmology.
    Loteprednol Etabonate
  • HY-B0328
    Triamcinolone
    		Inhibitor 99.86%
    Triamcinolone is a long-acting corticosteroid with anti-inflammatory, anti-oedematous, anti-proliferative, anti-angiogenetic, immunomodulatory and neuroprotective effects through binding to glucocorticoid receptors. Triamcinolone can relieve several dermatitis, immune diseases and ocular diseases.
    Triamcinolone
  • HY-13609
    Deflazacort
    		Agonist 98.98%
    Deflazacort, a glucocorticoid, is an inactive proagent and is converted rapidly to the active metabolite 21-desacetyldeflazacort. Deflazacort is used as an anti-inflammatory and immunosuppressant.
    Deflazacort
  • HY-B0625
    Ciclesonide
    		Agonist 99.93%
    Ciclesonide (RPR251526) is a glucocorticoid with an potent anti-inflammatory activity. Ciclesonide can be used for asthma research.
    Ciclesonide
  • HY-111490
    Desisobutyryl-ciclesonide
    		Modulator 99.53%
    Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor.
    Desisobutyryl-ciclesonide
  • HY-14930A
    Mirodenafil dihydrochloride
    		Modulator 99.85%
    Mirodenafil (SK3530) dihydrochloride is an orally active, potent, reversible, and selective phosphodiesterase 5 (PDE5) inhibitor. Mirodenafil dihydrochloride is a glucocorticoid receptor (GR) modulator Mirodenafil dihydrochloride activates the Wnt/β-catenin signaling pathway by downregulating Dkk1 expression. Mirodenafil dihydrochloride can be used for the research of erectile dysfunction (ED), Alzheimer’s disease (AD) and systemic sclerosis (SSc).
    Mirodenafil dihydrochloride
  • HY-B0645
    Prednisolone disodium phosphate
    		Agonist 99.79%
    Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
    Prednisolone disodium phosphate
  • HY-B0415
    Fluocinolone (Acetonide)
    		Agonist 99.68%
    Fluocinolone is a glucocorticoid glucocorticoid receptor agonist. Fluocinolone is effective in preventing both lipid accumulation and inflammation. Fluocinolone can promote the proliferation of DPCs and has the potential role in repairing injured pulp tissues. Fluocinolone can be used to study the prevention of chemotherapy-induced peripheral neuropathy caused by Paclitaxel (HY-B0015).
    Fluocinolone (Acetonide)
  • HY-15709
    AL 082D06
    		Antagonist 99.03%
    AL 082D06 is a selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM.
    AL 082D06
  • HY-B1060
    Methylprednisolone succinate sodium
    		Agonist 99.04%
    Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium, a glucocorticoid, is a immunosuppressive agent with anti-inflammatory effects.
    Methylprednisolone succinate sodium
  • HY-13571A
    Beclometasone dipropionate
    		Agonist 99.89%
    Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma .
    Beclometasone dipropionate
  • HY-B1540
    Beclometasone
    		Agonist 99.78%
    Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist.
    Beclometasone
  • HY-B1900
    Methylprednisolone succinate
    		Agonist 99.11%
    Methylprednisolone succinate is a synthetic glucocorticoid and widely used as an anti-inflammatory agent.
    Methylprednisolone succinate
  • HY-15234
    Fluticasone furoate
    		Activator 99.84%
    Fluticasone furoate is a topical, intranasal, enhanced-affinity synthetic trifluorinated corticosteroid with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflamatory and anti-asthmatic activity, and low systemic exposure. Fluticasone furoate has the potential for allergic rhinitis treatment.
    Fluticasone furoate
Cat. No. Product Name / Synonyms Application Reactivity